// Using fetch API
async function getVariant(variantId) {
  try {
    const response = await fetch(
      `https://variantbase.com/api/variants/${variantId}.json`
    );
    
    if (!response.ok) {
      throw new Error(`HTTP ${response.status}: ${response.statusText}`);
    }
    
    const variant = await response.json();
    return variant;
  } catch (error) {
    console.error('Variant lookup failed:', error);
    return null;
  }
}

// Usage
const variant = await getVariant('BRCA1_c.68_69del');
if (variant) {
  console.log('Clinical significance:', variant.clinical_significance.interpretation);
  console.log('ACMG criteria:', variant.clinical_significance.acmg_criteria);
}

import requests
import json

class VariantBaseAPI:
    def __init__(self, base_url="https://variantbase.com/api"):
        self.base_url = base_url
    
    def get_variant(self, variant_id):
        """
        Retrieve variant information by ID
        
        Args:
            variant_id (str): Variant identifier (e.g., 'BRCA1_c.68_69del')
        
        Returns:
            dict: Variant data or None if not found
        """
        url = f"{self.base_url}/variants/{variant_id}.json"
        
        try:
            response = requests.get(url, timeout=10)
            response.raise_for_status()
            return response.json()
        except requests.exceptions.RequestException as e:
            print(f"API request failed: {e}")
            return None

# Usage example
api = VariantBaseAPI()
variant = api.get_variant('BRCA1_c.68_69del')

if variant:
    print(f"Gene: {variant['gene']}")
    print(f"Clinical significance: {variant['clinical_significance']['interpretation']}")
    print(f"ACMG criteria: {', '.join(variant['clinical_significance']['acmg_criteria'])}")
    print(f"Population frequency: {variant['population_data']['gnomad']['allele_frequency']}")
else:
    print("Variant not found")

# Install required packages if needed
# install.packages(c("httr", "jsonlite"))

library(httr)
library(jsonlite)

# Function to query VariantBase API
get_variant <- function(variant_id, base_url = "https://variantbase.com/api") {
  url <- paste0(base_url, "/variants/", variant_id, ".json")
  
  tryCatch({
    response <- GET(url, timeout(10))
    
    if (status_code(response) == 200) {
      content <- content(response, "text", encoding = "UTF-8")
      variant_data <- fromJSON(content)
      return(variant_data)
    } else {
      warning(paste("API request failed with status:", status_code(response)))
      return(NULL)
    }
  }, error = function(e) {
    warning(paste("Request error:", e$message))
    return(NULL)
  })
}

# Usage example
variant <- get_variant("BRCA1_c.68_69del")

if (!is.null(variant)) {
  cat("Gene:", variant$gene, "\n")
  cat("Clinical significance:", variant$clinical_significance$interpretation, "\n")
  cat("ACMG criteria:", paste(variant$clinical_significance$acmg_criteria, collapse = ", "), "\n")
  cat("Population frequency:", variant$population_data$gnomad$allele_frequency, "\n")
} else {
 cat("Variant not found\n")
}